

PLANT RESEARCH BREIFING PAPERS - Plant Research May Help Reduce Anemia in Humans
Diggle,
a mutant pea plant with a
suicidal love for iron, may
someday offer scientists a
biotechnology approach for
reducing anemia.
Anemia,
or iron-poor blood, affects
2 billion people--about one-third
of the world's population, according
to World Health Organization
statistics. Inadequate iron
in the diet is the leading cause.
Plant
physiologist Michael Grusak
at the Agricultural Research
Service would like to understand
and modify Diggle's "stupid
plant trick." ARS is the USDA's
chief scientific agency.
Grusak's
major aim: improve the iron
content of staple crops such
as rice. This would especially
benefit people in developing
countries, who mostly eat vegetarian
diets. Only 5 percent of the
iron in plants is bioavailable--usable
by the body as a nutrient. By
contrast, 30 to 50 percent of
iron in meat is usable.
Plants
hoard iron, using a protein,
ferritin, to store it in seeds
and leaves. But ferritin also
binds iron, making it hard for
the body to use.
Rice
has only 6 parts per million
iron after milling. Most pea
seeds have 60 ppm, so that,
pound for pound, peas' 5 percent
of bioavailable iron yields
more of the nutrient than rice.
Diggle peas have a whopping
250 to 280 ppm iron. The plant
ships so much of this essential
mineral to leaves and seeds
that it eventually poisons itself.
All
plants move iron to seeds with
a special biochemical. Grusak's
hypothesis is that Diggle employs
a different transport chemical.
If
Diggle's trait is genetic and
transferable to other crops,
the idea would be to turn it
"on" when a crop is making seeds,
but keep it "off" at other times
so the plant doesn't overdose
on the nutrient.
Diggle's
name comes from its genetic
classification, "dgl," scientific
shorthand for "degenerative
leaves." The leaves are marked
by numerous tiny dark spots.